from PIL import Image, ImageDraw

im = Image.open('d:/tmp/58.249.0.220_01_20200604141800866_TIMING.jpg', 'r')
im2 = Image.open('d:/tmp/58.249.0.220_01_20200604141800866_TIMING.jpg', 'r')
draw = ImageDraw.Draw(im2)
draw.rectangle([(1000, 500), (1200, 800)], fill=(255, 0, 0), width=2)
out = Image.blend(im, im2, 0.5)
out.save('d:/tmp/demo1.jpg')
im.close()
im2.close()
out.show()
out.close()

from PIL import Image, ImageDraw

im = Image.open('d:/tmp/58.249.0.220_01_20200604141800866_TIMING.jpg', 'r')
b = (255, 0, 0)
opacity = 0.5

for x in range(1000, 1200):
  for y in range(500, 800):
    p = im.getpixel((x, y))
    p = [int(p[i]*(1-opacity) + b[i]*opacity) for i in range(3)]
    im.putpixel((x, y), tuple(p))

im.save('d:/tmp/demo2.jpg')
im.show()
im.close()